《生命科学》 2019, 31(11): 1164-1172

血管内皮下蛋白聚糖与低密度脂蛋白的相互作用

陆金燕1，杨佳丽1，邓小燕1，康红艳2*

(1 北京航空航天大学生物与医学工程学院，生物力学与力生物学教育部重点实验室，北京 100083；2 北京航空航天大学生物医学工程高精尖创新中心，北京 100083)

摘　要：摘　要：研究表明，蛋白聚糖和低密度脂蛋白相互作用而使低密度脂蛋白在血管壁滞留、沉积是动脉粥样硬化整个过程中的初发事件。蛋白聚糖通常由一个核心蛋白骨架和一个或多个共价连接的糖胺聚糖链组成，主要有基底膜蛋白聚糖(perlecan)、双糖链蛋白聚糖(biglycan)、多功能蛋白聚糖(versican)、核心蛋白聚糖(decorin) 等。在对四类蛋白聚糖进行简要叙述的基础上，现着重对四类蛋白聚糖与低密度脂蛋白的相互作用关系加以综述。

Interaction of proteoglycans with low density lipoprotein on the vascular endothelium

LU Jin-Yan1， YANG Jia-Li1， DENG Xiao-Yan1， KANG Hong-Yan2*

(1 Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education，
    School of Biological Science and Medical Engineering， Beihang University， Beijing 100083， China; 2 Beijing Advanced Innovation Center for Biomedical Engineering， Beijing 100083， China)

Abstract: Abstract: Interactions between proteoglycans and low-density lipoproteins may lead to low-density lipoprotein retention and deposition in the vessel wall， which is an initial event in the entire process of atherosclerosis. Proteoglycans are usually composed of one core protein backbone with one or more glycosaminoglycan chains covalently linked， mainly including perlecan， biglycan， versican， decorin and so on. Thus， with a brief description of these four types of proteoglycans， this review presents the interactions between the four types of proteoglycans and low-density lipoproteins.