《生命科学》 2019, 31(11): 1158-1163

长链非编码RNA对骨质疏松症调控作用的研究进展

刘莉菲1，2，周绪昌1，邹　军1*

(1 上海体育学院运动科学学院，上海 200438；2 中国医科大学人民医院辽宁省人民医院康复医学科，沈阳 110016)

摘　要：摘　要：骨质疏松症是以骨密度减低和骨微结构破坏为特征的骨代谢性疾病，可引起骨脆性增加和骨折风险增大。近年来，随着骨质疏松症病因研究的深入，基因领域的机制研究获得了更多发现。长链非编码RNA 参与多种生理和病理变化，已成为控制基因表达和影响多种生物过程的重要表观遗传调节因子。大量研究表明，长链非编码RNA 能够通过调控干细胞分化和骨重塑等过程对骨质疏松症产生影响。该文主要针对长链非编码RNA 对干细胞、成骨细胞及破骨细胞增殖、分化调控作用进行综述，旨在探讨长链非编码RNA 在骨质疏松症形成机制中的调控作用，为骨质疏松症的预防和临床治疗提供理论依据。

Advances in the regulation of long-chain non-coding RNA on osteoporosis

LIU Li-Fei1，2， ZHOU Xu-Chang1， ZOU Jun1*

(1 School of Kinesiology， Shanghai University of Sport， Shanghai 200438， China; 2 Rehabilitation Department， People’s Hospital of China Medical University， People's Hospital of Liaoning Province， Shenyang 110016， China)

Abstract: Abstract: Osteoporosis is a bone metabolic disease characterized by decreased bone density and bone microstructural destruction， which can cause increased bone fragility and fracture risk. Recent years， the mechanism research of genes has gained more discoveries with the development of research on osteoporosis. Long noncoding RNAs are involved in a variety of physiological and pathological processes and have become important epigenetic regulators which control gene expression and affect a variety of biological processes. Increasing evidence shows that long noncoding RNAs are involved in the regulation of stem cell differentiation and bone remodeling， thereby affecting the formation of osteoporosis. This article reviews the regulation of long noncoding RNAs on the proliferation and differentiation of stem cells， osteoblasts and osteoclasts， aiming to investigate the role of long noncoding RNAs in the pathogenesis of osteoporosis， and provide a theoretical basis for the prevention and clinical treatment of osteoporosis.