《生命科学》 2019, 31(11): 1126-1132
摘 要：摘 要：间充质干细胞(mesenchymal stem cells， MSCs) 是一种具有自我更新及多向分化潜能的多能干细胞。MSCs 的多向分化潜能、旁分泌和免疫调控功能在损伤组织修复、再生和细胞治疗方面显示出巨大的临床应用前景。能量代谢是细胞新陈代谢的重要内容和细胞功能实现的重要基础，能量代谢的变化与细胞多种生物学行为的改变密切相关。干细胞分化过程中能量代谢发生了改变，而改变干细胞的能量代谢途径也能调控干细胞的分化命运，因此干细胞与能量代谢之间相互影响。现就MSCs 的分化与能量代谢之间的关系进行综述。
Abstract: Abstract: Mesenchymal stem cells (MSCs) are subpopulation of cells that have self-renewal and multilineage differentiation capability. MSCs show great potential on clinical applications， including tissue repair and regeneration， as well as cell-based therapy mainly through their multilineage differentiation capability， paracrine and immunoregulation. Energy metabolism is the key content of cell metabolism and plays an important role in maintaining cellular functions. The alterations of energy metabolism will affect the cellular behaviors. During the differentiation process， stem cells will undergo metabolic shift， and the alteration of energy metabolism would also regulate the lineage determination of stem cells. Therefore， stem cell and energy metabolism could influence each other. This review focuses on the relationship between differentiation and energy metabolism of MSCs.
