《生命科学》 2019, 31(10): 1060-1068

维生素D与代谢性炎症的研究进展

高　玲1，2，袁　天3，陈代娣4，尹琳洁1，陈业史5，阳　敏1，童　瑶6，尹　凯2*，桂庆军1*

(1 南华大学衡阳医学院转化医学研究室，衡阳 421000；2 南华大学附属第一医院心血管内科，衡阳 421000；3 武汉理工大学交通学院， 武汉 430063；4 南华大学公共卫生学院，衡阳 421000；5 南华大学护理学院， 衡阳 421000；6 南华大学衡阳医学院临床医学系，衡阳 421000)

摘　要：摘　要：维生素D (vitamin D， VitD) 是一类固醇类衍生物，活性维生素D 通过与维生素D 受体(VDR) 结合发挥多种生物学功能，除了与骨骼的生长发育相关之外，其对脂肪、肝脏及肾脏等多种组织器官的功能具有重要的调节作用。肥胖诱导的代谢性炎症与心血管疾病、糖尿病、代谢综合征等疾病密切相关，然而，维生素D 与肥胖引发的代谢性炎症是否有直接的联系尚不明确。为此，该文对维生素D 与代谢性炎症之间的关系作综述，以便揭示维生素D 在代谢性炎症防治中的作用。

Research progress of the relationship between vitamin D and metabolic inflammation

GAO Ling1，2， YUAN Tian3， CHEN Dai-Di4， YIN Lin-Jie1， CHEN Ye-Shi5， YANG Min1， TONG Yao6 ， YIN Kai2*， GUI Qing-Jun1*

(1 Research Lab of Translational Medicine， Hengyang Medical school， University of South China， Hengyang 421001， China; 2 Department of Cardiology， The First Affiliated Hospital of University of South China， Hengyang 421001， China; 3 School of Transportation， Wuhan University of Techonology， Wuhan 430063， China; 4 Public Sanitation College， University of South China， Hengyang 421001， China; 5 School of Nursing， University of South China， Hengyang 421001， China; 6 Clinical Medicine Department， Hengyang Medical school， University of South China， Hengyang 421001， China)

Abstract: Abstract: Vitamin D (VitD) is a steroid derivative. Activated vitamin D exerts various biological functions by binding to vitamin D receptor (VDR). In addition to being associated with bone growth and development， it has an important regulatory effect on the functions of various tissues and organs such as fat， liver and kidney. Obesityinduced metabolic inflammation is closely related to diseases such as cardiovascular diseases， diabetes， and metabolic syndrome. However， it is not clear whether vitamin D is directly related to the metabolic inflammation caused by obesity. Therefore， this article reviews the relationship between vitamin D and metabolic inflammation， which may be able to reveal the role of vitamin D in the prevention and treatment of metabolic inflammation.