《生命科学》 2019, 31(10): 1054-1059
摘 要：摘 要：肝纤维化是各种病因引起肝损伤后细胞外基质沉积或瘢痕形成的过程，可持续进展为肝硬化，甚至肝癌等终末期肝脏疾病，严重危害人类健康。间充质干细胞(mesenchymal stem cells， MSCs) 是一类具有多向分化潜能的多能干细胞，近年来被广泛应用于多种疾病治疗。现今，MSCs 移植已被运用于肝纤维化治疗研究，治疗结局众说纷纭，其作用机制莫衷一是。现就MSCs 通过免疫、炎症、归巢等途径对肝纤维化进展的调控机制做一综述。
Abstract: Abstract: Liver fibrosis was a process of extracellular matrix deposition or scar formation after liver injury caused by various causes. Once hepatic fibrosis develops into end-stage liver diseases， such as cirrhosis and hepatocellular carcinoma， it greatly harms human health. Mesenchymal stem cells (MSCs) are a class of pluripotent stem cells with multi-directional differentiation potential and have been widely used in the treatment of various diseases in recent years. Nowadays， MSCs transplantation therapy has been tried to apply to liver fibrosis. There were many different opinions on the treatment outcome， and the related mechanisms were inconsistent. This article reviews the regulation mechanism of MSCs on the progression of liver fibrosis through immune， inflammation， and homing.
