《生命科学》 2019, 31(10): 1035-1040
摘 要：摘 要：抑郁症是一种严重的精神疾病，具有患病率高、致残率高和自杀率高等特点，给社会带来沉重的负担。目前针对抑郁症的治疗主要以药物治疗为主，且普遍存在起效慢、药物耐受、副作用多、易复发以及疗效时间有限等局限性，使得抗抑郁治疗亟需开发新的策略。近年研究发现，在抑郁症动物模型中调节神经营养因子的表达水平可调控神经细胞存活，促进神经发生，提高神经元可塑性等，从而发挥抗抑郁作用。这为临床抗抑郁治疗提供了新的策略。本文主要介绍几种重要的神经营养因子对抑郁行为的影响及其应用于抗抑郁治疗的研究新进展。
Abstract: Abstract: Depression is a widespread devastating mental illness with high prevalence， high disability rate and suicide rate， bringing a heavy burden to the patients and society. Currently， antidepressant treatment is mainly based on chemical drugs， but there are many limitations including relatively low efficiency， drug resistance， multiple side effects and time lag for treatment. It is thus urgent to develop new antidepressant strategies for more efficacious and fast-acting antidepressant agents. Recent studies have found that neurotrophic factors may play antidepressant role in the brain through regulation of neuronal survival， promotion on hippocampal neurogenesis and enhancement of neural plasticity， providing novel insights into the clinical antidepressant therapy. This article mainly reviews the role of several important neurotrophic factors in pathogenesis of depression and their anti-depression effects.
