《生命科学》 2019, 31(10): 1025-1034

血管内皮细胞外泌体的生物学作用及其分子机制的研究进展

罗俊容，潘美伶，王玉洁，杜小强，高文博，曾　烨*

(四川大学华西基础医学与法医学院生物医学工程研究室，成都 610041)

摘　要：摘　要：外泌体是细胞分泌的一种纳米级胞外囊泡，通过携带蛋白质和核酸等小分子物质参与细胞间信号交流。内皮细胞来源的外泌体在许多病理生理过程中起着十分重要的作用。现综述血管内皮细胞外泌体的生物学作用及其分子机制的最新研究进展，重点关注血管内皮细胞外泌体在心血管疾病、缺血再灌注损伤、肿瘤发生发展和免疫调节等过程中的重要作用，及其调控受体细胞功能的分子机制。

Research advances on the biological function and molecular mechanism of exosomes derived from vascular endothelial cells

LUO Jun-Rong， PAN Mei-Ling， WANG Yu-Jie， DU Xiao-Qiang， GAO Wen-Bo， ZENG Ye*

(Institute of Biomedical Engineering， West China School of Basic Medical Sciences and Forensic Medicine， Sichuan University， Chengdu 610041， China)

Abstract: Abstract: Exosomes are a kind of nano-scale extracellular vesicles secreted by cells such as endothelial cells， which are involved in intercellular communication by carrying small molecules such as proteins and nucleic acids. It has been reported that the vascular endothelial cell-derived exosomes play an important role in many pathophysiological processes. This review summarized the recent advances in the biological role of endothelial cell-derived exosomes and their molecular mechanisms， with a focus on the vital roles of endothelial cell-derived exosomes in cardiovascular diseases， ischemia-reperfusion injury， tumorigenesis， immune regulation， and their molecular mechanism of regulating the receptor cell function.