《生命科学》 2019, 31(9): 908-920
摘 要：摘 要：高等植物的生长发育依赖于顶端分生组织的维持和定向分化。顶端分生组织一方面需要维持自身的结构，同时又需要通过特定细胞的分化来起始各种器官的发育，这就需要通过精准的调控来决定各个细胞的命运。其中，染色质重塑就是一类广泛参与这些命运决定过程的调控方式。染色质重塑通过形成一系列重塑复合体对染色质修饰进行精确控制，影响各类转录调节因子与染色质结合的难易程度，进而使细胞感受各种信号和环境剌激，并在调控基因时空特异性表达与沉默方面发挥重要作用，形成一系列分子开关。现概述染色质重塑参与顶端分生组织调控的最新研究进展，梳理参与该调控的各类途径及重要调控因子，并展望该领域未来的研究方向。
Abstract: Abstract: The growth and development of plants depend on the maintenance and directional differentiation of apical meristem. Thus， the apical meristem must maintain their structures. Furthermore， the apical meristem initiate the development of various organs through the differentiation of specific cells. Therefore， precise regulation is required in the determination of the fate of each cell. Chromatin remodeling is a kind of regulation mode that extensively participates in these fate-determining processes. Chromatin remodeling affects the binding of various transcription factors to chromatin through the precise control of chromatin modification by a series of complexes， thus making cells feel the stimulation from various signals and environments. This process plays an important role in the regulation of spatiotemporal specific expression， silencing of genes， and formation of a series of molecular switches. In this paper， we summarize the latest research progress of chromatin remodeling for regulating apical meristem， explore various pathways and important regulatory factors involved in this regulation， and propose future research directions in this field.
