《生命科学》 2019, 31(9): 894-901

海洋来源硫酸软骨素降解酶的研究进展

王文爽，许莹莹，石立冉，李福川*

(山东大学国家糖工程技术研究中心，青岛 266237)

摘　要：摘　要：硫酸软骨素作为糖胺聚糖的一类，广泛分布于细胞膜表面及细胞基质中，参与了一系列生理和病理过程。硫酸软骨素的功能多样性与其结构多样性密切相关，而硫酸软骨素降解酶在硫酸软骨素/ 硫酸皮肤素构效关系研究中发挥了重要作用。该文结合笔者工作，全面阐述了目前商品化硫酸软骨素降解酶的种类、作用机制，以及近期在海洋细菌中发现和鉴定的硫酸软骨素降解酶。最后，对海洋来源硫酸软骨素降解酶进行了展望。

Research progress in chondroitinase from marine bacteria

WANG Wen-Shuang， XU Ying-Ying， SHI Li-Ran， LI Fu-Chuan*

(National Glycoengineering Research Center， Shandong University， Qingdao 266237， China)

Abstract: Abstract: As a class of glycosaminoglycans， chondroitin sulfate is widely distributed on the cell membrane surface and in the cell matrix， and participates in a series of physiological and pathological processes. The functional diversity of chondroitin sulfate is closely related to its structural diversity， and chondroitin sulfate-degrading enzymes play a huge role in the study of chondroitin sulfate/dermatan sulfate structure-activity relationship. This paper comprehensively illuminates the types and mechanisms of commercial chondroitin sulfate-degrading enzymes and the chondroitin sulfate-degrading enzymes recently discovered and identified in the marine bacteria. Finally， the marine source enzymes are prospected.