《生命科学》 2019, 31(9): 886-893

铁死亡及其在心脑血管疾病中的研究进展

王梅芳，李德冠*

(中国医学科学院&北京协和医学院放射医学研究所，天津市放射医学与分子核医学重点实验室，天津 300192)

摘　要：摘　要：铁死亡是一种程序性细胞死亡方式，其发生伴随铁依赖性脂质活性氧的积累和质膜多不饱和脂肪酸的消耗，涉及脂质代谢、氨基酸代谢和铁代谢三个过程。心脑血管疾病严重危害人类健康，是心脏血管和脑血管疾病的综合，铁死亡在其发病过程中发挥了至关重要的作用。现主要围绕铁死亡的机制及其在心脏血管和脑血管疾病中的影响等相关问题进行综述，从而为相关疾病的防治提供参考。

Research progress of ferroptosis in cardiovascular and cerebrovascular diseases

WANG Mei-Fang， LI De-Guan*

(Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine， Institute of Radiation Medicine， Chinese Academy of Medicine Science & Peking Union Medical College， Tianjin 300192， China)

Abstract: Abstract: Ferroptosis is a kind of programmed cell death， which is accompanied by the accumulation of irondependent lipid and reactive oxygen species and the consumption of plasma membrane polyunsaturated fatty acids， involving lipid metabolism， amino acid metabolism and iron metabolism. Cardiovascular and cerebrovascular diseases are a serious threat to human health and are a combination of cardiovascular and cerebrovascular diseases. Ferroptosis plays a vital role in their pathogenesis. This article focuses on the mechanism of ferroptosis and its effects in cardiovascular and cerebrovascular diseases， in order to provide a reference for the prevention and treatment of related diseases.