《生命科学》 2019, 31(9): 871-878

布鲁氏菌逃避宿主免疫机制的研究进展

谢士杰，彭小薇，冯　宇，许冠龙，丁家波，范学政*

(中国兽医药品监察所国家/OIE动物布鲁氏菌病参考实验室，北京 100081)

摘　要：摘　要：布鲁氏菌病是由布鲁氏菌引起的一种人畜共患性传染病，可以对畜牧业生产和人类健康造成严重的危害。布鲁氏菌是兼性胞内寄生菌，在长期与宿主免疫系统的相互作用中，进化出了多种逃避宿主免疫应答的机制。该文主要概述了布鲁氏菌胞内循环过程和逃避宿主先天性免疫应答和适应性免疫应答的机制，以及通过激活非典型自噬途径、抑制细胞凋亡、调控细胞焦亡等方式建立慢性感染的策略，以期为进一步深入研究布鲁氏菌病以及病原与宿主的相互作用提供参考。

Mechanism of Brucella evading from host immune response

XIE Shi-Jie， PENG Xiao-Wei， FENG Yu， XU Guan-Long， DING Jia-Bo， Fan Xue-Zheng*

(National/OIE Reference Laboratory for Animal Brucellosis， China Institute of Veterinary Drug Control， Beijing 100081， China)

Abstract: Abstract: Brucellosis is a zoonotic infection caused by Brucella that can cause serious harm to livestock production and human health. Brucella is a facultative intracellular parasite that has evolved a variety of mechanisms to evade host immune responses from the long-term interaction with the host immune system. In this review， we mainly summarize the mechanisms of intracellular circulation of Brucella， its evasion from host innate immune response and adaptive immune response， and the strategies for establishing chronic infection by activating atypical autophagy， inhibiting apoptosis and regulating pyroptosis. It is expected to provide a reference to further study of brucellosis and pathogen interaction with host.