《生命科学》 2019, 31(9): 865-870

宿主模式识别受体介导的病毒免疫逃逸机制研究进展

李　倩1，2，李向茸1，冯若飞1*

(1 西北民族大学生物医学研究中心，生物工程与技术国家民委重点实验室，兰州 730030；
    2 西北民族大学生命科学与工程学院，兰州 730030)

摘　要：摘　要：随着病毒和机体斗争的不断发展，病毒逐步进化出各种免疫逃逸机制来躲避宿主的免疫应答，以实现增殖的目的。该文归纳总结了病毒通过宿主的Toll 样受体、RIG-I 样受体、DNA 识别受体及NOD 样受体等主要模式识别受体进行逃逸的机制，并且为深入探究病毒致病机制奠定基础，也为病毒疫苗和抗病毒药物的研发提供了新思路。

Advances in research on the mechanisms of viruses escape mediated by host pattern recognition receptors

LI Qian1，2， LI Xiang-Rong1， FENG Ruo-Fei1*

(1 Biomedical Research Center， Key Laboratory of Biotechnology & Bioengineering of
    State Ethnic Affairs Commission， Northwest Minzu University， Lanzhou 730030， China;
    2 College of Life Science and Engineering， Northwest Minzu University， Lanzhou 730030， China)

Abstract: Abstract: Viruses have evolved various strategies to escape from the innate cellular mechanisms inhibiting viral replication and spread. This paper reviewed the evasion mechanism of viruses through the host's pattern recognition receptors， such as Toll like receptor， RIG-I like receptor， DNA sensor， and NOD like receptor. Understanding the associated mechanisms of viral evasion not only has the potential to clarify viral pathogenicity， but also improves vaccine and experimental therapy design.