《生命科学》 2019, 31(8): 802-811

结肠癌干细胞标志物和信号通路的研究进展

张子怡1#，林泉任1#，叶春雨2#，金　燕2*

(1 延边大学医学院，延吉 133002；2 延边大学医学院细胞生物学与医学遗传学教研室，延吉 133002)

摘　要：摘　要：结肠癌是一种最常见的消化道恶性肿瘤，世界范围内其发病率位列第三。大部分的结肠癌患者死亡由肿瘤的复发转移和耐药性所致，而这些过程都有肿瘤干细胞的参与。因此，靶向肿瘤干细胞将成为未来根治结肠癌的重要研究方向，而结肠癌干细胞标志物的发现则为其提供了新思路。同时，因结肠癌干细胞的生长依赖多种信号通路的作用，故其相关信号通路靶向药物的研究也将是一大发展方向。该文就目前关于结肠癌干细胞标志物及其相关信号通路抑制剂的研究进展作一综述。

Advances in research on stem cell markers and signaling pathways in colon cancer

ZHANG Zi-Yi1#， LIN Quan-Ren1#， YE Chun-Yu2#， JIN Yan2*

(1 College of Medicine， Yanbian University， Yanji 133002， China; 2 Department of Cell Biology and Medical Genetics， College of Medicine， Yanbian University， Yanji 133002， China)

Abstract: Abstract: Colon cancer is one of the most common malignant tumors of the digestive tract， and its incidence ranks third in the world. Most patients with colon cancer die of tumor recurrence and metastasis as well as drug resistance， which are related to cancer stem cells. Therefore， targeting cancer stem cells will become an important research direction for radical cure of colon cancer in the future， and the discovery of colon cancer stem cell markers opens a new window for it. Moreover， since the growth of colon cancer stem cells depends on various signaling pathways， the research on targeted drugs of colon cancer stem cell-related signaling pathways will also be a major development direction. In this paper， the current research progress on cancer stem cell markers and inhibitors of related signaling pathway in colon cancer is reviewed.