《生命科学》 2019, 31(8): 795-801

Beclin-1非自噬依赖性通路在肿瘤中的研究进展

应　杰1，王　梦1，张　蒙1，2*，梁朝朝1*

(1 安徽医科大学第一附属医院泌尿外科，合肥 230022；2 深圳大学附属罗湖医院泌尿外科，深圳 518000)

摘　要：摘　要：Beclin-1 作为重要的自噬调节因子在肿瘤发生和进展过程中起到重要作用。然而近年来越多越多的研究揭示，除调控自噬外，Beclin-1 还可通过非自噬依赖性通路调控生长因子受体信号通路、协助细胞有丝分裂、促进DNA 损伤修复以及间接促进肿瘤细胞凋亡进程，进 而影响肿瘤发生和进展。该文将对Beclin-1 在肿瘤中的非自噬依赖性功能进行综述。

Advances in the research of autophagy-independent pathways of Beclin-1 in tumors

YING Jie1， WANG Meng1， ZHANG Meng1，2*， LIANG Chao-Zhao1*

(1 Department of Urology， The First Affiliated Hospital of Anhui Medical University， Hefei 230022， China; 2 Department of Urology， Luohu Hospital of Shenzhen University， Shenzhen 518000， China)

Abstract: Abstract: As an important regulator of autophagy， Beclin-1 plays a crucial role in tumor initiation and progression. However， an increasing number of studies have revealed that， in addition to regulating autophagy， Beclin-1 could
    also influence tumorigenesis and progression via regulating growth factor receptor signaling， assisting mitosis， promoting DNA damage repair and indirectly increasing cell apoptosis which are autophagy-independent. This
    review summarizes the autophagy-independent roles of Beclin-1 in tumors.