《生命科学》 2019, 31(8): 787-794

Th17分化调控与多发性硬化症及其治疗新策略

尹倩梅1，苏泽红2，喻翠云3，练高建4*

(1 南华大学衡阳医学院，衡阳 421001；2 南华大学生物化学与分子生物学教研室，衡阳 421001；3 湖南省分子靶标新药研究协同创新中心，衡阳 421001；4 南华大学医学研究中心，衡阳 421001)

摘　要：摘　要：多发性硬化症(multiple sclerosis， MS) 是一种由T 细胞介导、以中枢神经脱髓鞘及神经元病变为主要病理特征的自身免疫性疾病。该病的致病机制尚未明确，且目前无法彻底治愈，只能通过药物来缓解病理进程。因此，寻找MS 的有效治疗途径尤为重要。研究发现，Th17 细胞与MS 疾病的发生与发展密切相关，而T 细胞分化为Th17 细胞又受到多方面因素的影响，其中miRNA 和代谢程序调控在此过程中发挥重要作用。现对Th17 细胞及MS 相关的最新研究进展进行综述，重点讨论了Th17 细胞的分化调控和MS 治疗的一些新策略。

Regulation of T helper 17 cells differentiation: pathogenic role and potential therapy in multiple sclerosis

YIN Qian-Mei1， SU Ze-Hong2， YU Cui-Yun3， LIAN Gao-Jian4*

(1 Hengyang Medical College， University of South China， Hengyang 421001， China;
    2 Department of Biochemistry and Molecular Biology， University of South China， Hengyang 421001， China; 3 Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study， Hengyang 421001， China; 4 Medical Research Center， University of South China， Hengyang 421001， China)

Abstract: Abstract: multiple sclerosis (MS) is an autoimmune disease， which mediated by T cells and characterized by central nervous demyelinating and neuronal lesions. However， the pathogenesis mechanism of MS is still unclear， and this disease cannot be completely cured at present. Only drugs can be used to alleviate the pathological process. Therefore， it is particularly crucial to find an effective way for the treatment of MS. It has been found that Th17 cells are closely related to the occurrence and development of MS， and the differentiation of Th17 cells is regulated by various factors， such as miRNA and metabolic program regulation. In this paper， we reviewed the latest research progresses of Th17 cells and MS， focusing on the differentiation regulation of Th17 cells and some new strategies for MS treatment.