《生命科学》 2005, 17(2):

蛋白激酶AMPK的研究进展

符庆瑛，高钰琪^*

第三军医大学病理生理学与高原生理学教研室，军队高原生理与高原病研究重点实验室，重庆 400038

摘　要：摘　要：AMP激活的蛋白激酶(AMP-activated protein kinase, AMPK)广泛存在于真核细胞中，一旦被激活，即可磷酸化下游靶蛋白，关闭消耗ATP的合成代谢途径，开启产生ATP的分解代谢途径，被称为“细胞能量调节器”。许多新的下游靶蛋白的发现也为AMPK生物学效应的阐明提供了新思路。
关键词：AMPK；能量代谢；AMP

Advances in the studies of AMP-activated protein kinase

FU Qing-Ying, GAO Yu-Qi^*

Key Laboratory of High Altitude Physiology and Mountain Sickness of PLA, Department of Pathophysiology and High Altitude Physiology, Third Military Medical University, Chongqing 400038, China

Abstract: Abstract: The AMP-activated protein kinase is found in all eukaryotic cells. Once activated, the kinase switches on ATP-producing catabolic pathways and switches off ATP-consuming processes,both via direct phosphorylation of downstream targets, and thus is called a “cellular energy regulator”. A variety of novel downstream target proteins have been discovered recently, which provide new insight into elucidating precise functions of AMP-activated protein kinase.
Key words: AMP-activated protein kinase; energy metabolism; adenosine monophosphate