《生命科学》 2019, 31(8): 756-762

长寿基因SIRT2在老年病中的调控作用

罗苏苏1，李鹏程2，钱　峰2*，韩颖颖1*

(1 上海理工大学医疗器械与食品学院，上海 200093；2 复旦大学生命科学学院，上海 200433)

摘　要：摘　要：SIRT2 是一种NAD+ 依赖的去乙酰化酶，可通过去乙酰化作用于组蛋白和非组蛋白，调节底物的活性与稳定性，参与代谢、氧化应激和炎症等多个衰老相关生理过程。在衰老过程中，活性氧大量积累，氧化应激加剧，并伴随慢性炎症，这一系列过程增加了老年病风险，如神经退行性疾病、心血管疾病和2型糖尿病等。该文对SIRT2 在衰老过程及老年病中的调控作用进行了综述，以期为老年病相关的药物研发提供一些理论基础。

Regulation of longevity gene SIRT2 in aging-related diseases

LUO Su-Su1， LI Peng-Cheng2， QIAN Feng2*， HAN Ying-Ying1*

(1 School of Medical Instrument and Food Engineering， University of Shanghai for Science and Technology， Shanghai 200093， China; 2 School of Life Science， Fudan University， Shanghai 200433， China)

Abstract: Abstract: SIRT2 is a NAD+-dependent deacetylase that directly affects the stability and the function of target proteins. SIRT2 has been reported to regulate a variety of aging-related physiological processes， including metabolism， oxidative stress and inflammation. Aging is accompanied by massive accumulation of reactive oxygen species (ROS)， increased oxidative stress and chronic inflammation， leading to increased incidence of aging-related diseases， such as neurodegenerative diseases， cardiovascular diseases， and type 2 diabetes. This review summarizes the effect of SIRT2 on aging process and explores its potential as a therapeutic target for treatment of aging-related diseases.