《生命科学》 2019, 31(6): 551-557

外泌体源性miRNA在肿瘤发生发展中作用的研究进展

周致远1，唐旭东1，2，3*

(1 广东医科大学生物化学与分子生物学研究所，湛江 524023；2 广东医科大学抗肿瘤活性物质研发协同创新中心，湛江 524023；3 东莞市医学活性分子开发与转化重点实验室，东莞 523808)

摘　要：摘　要：外泌体作为细胞间信息交流的重要媒介，可携带蛋白质、脂质、核酸等多种信息物质到受体细胞中，使受体细胞产生不同的生化反应进而调节各项生命活动。近年来大量研究表明，外泌体源性miRNA 广泛参与包括肿瘤在内的多种疾病的发生发展。为了更好地了解外泌体源性miRNA 对肿瘤发生发展的影响，该文综述了外泌体源性miRNA 在肿瘤血管生成、上皮- 间质转化、免疫调节、转移前微环境、耐药等方面的作用。

Research progress on the role of exosomal miRNA in the occurrence and development of tumors

ZHOU Zhi-Yuan1， TANG Xu-Dong1，2，3*

(1 Institute of Biochemistry and Molecular Biology， Guangdong Medical University， Zhanjiang 524023， China; 2 Collaborative Innovation Center for Antitumor Active Substance Research and Development， Guangdong Medical University， Zhanjiang 524023， China; 3 Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research， Guangdong Medical University， Dongguan 523808， China)

Abstract: Abstract: Exosomes， the important cell-cell communication players， can carry a variety of signal molecules， such as proteins， lipids， and nucleic acids， into the recipient cells， allowing these cells to produce different biochemical
    reactions and regulate various life activities. In recent years， accumulating evidence has demonstrated that exosomal miRNAs participate extensively in the occurrence and development of multiple diseases， including tumors. In this
    review， we summarized the role of exosomal miRNAs in tumor angiogenesis， epithelial-mesenchymal transition， immunoregulation， pre-metastatic niche， and drug resistance to better understand the effects of exosomal miRNAs on the occurrence and development of tumors.