《生命科学》 2019, 31(5): 430-448

基于莽草酸途径微生物合成芳香族化合物及其衍生物的研究进展

江晶洁1，刘　涛2，林双君1*

(1 上海交通大学生命科学技术学院，微生物代谢国家重点实验室，上海 200240；
    2 中国科学院天津工业生物技术研究所，天津 300308)

摘　要：摘　要：芳香族化合物是一类重要的天然产物，在自然界中广泛存在，应用于食品、医药、化工等多个领域，主要通过化学合成、植物提取等方式获得。近年来，随着石化资源减少、人类环保意识的加强，微生物合成芳香族化合物及其衍生物成为热点。莽草酸途径合成的芳香族化合物及其衍生物多种多样。现重点综述通过莽草酸途径合成的“达菲”药物前体莽草酸、大宗化学品己二酸前体顺，顺- 粘康酸、芳香族氨基酸及其他高附加值芳香族氨基酸衍生物的微生物合成研究进展，为建立生产高附加值化合物的细胞工厂提供参考。

Research progress on the biosynthesis of aromatic compounds by microorganisms

JIANG Jing-Jie1， LIU Tao2， LIN Shuang-Jun1*

(1 The State Key Laboratory of Microbial Metabolism， School of Life Sciences & Biotechnology， Shanghai Jiao Tong University， Shanghai 200240， China;
    2 Tianjin Institute of Industrial Biotechnology， Chinese Academy of Sciences， Tianjin 300308， China)

Abstract: Abstract: Aromatic compounds are an important class of natural products. They are widely distributed in nature and are used in many fields such as food， medicine， and chemical industry. They are mainly obtained by chemical synthesis and plant extraction. In recent years， with the reduction of petrochemical resources and the enhancement of human environmental awareness， microbial synthesis of aromatic compounds and their derivatives has become a hot spot. The aromatic compounds and their derivatives synthesized by the shikimate pathway are diverse. This review focuses on the advances in the microbial synthesis of shikimic acid (the synthetic precursor of oseltamivir)， cis，cis-muconic acid (the precursor of the bulk chemical adipic acid)， aromatic amino acids， and other high value-added aromatic amino acid derivatives synthesized by the shikimate pathway. This review will provide some advice on the establishment of cell factories for the production of high value-added compounds.