《生命科学》 2019, 31(3): 284-288

mTOR信号通路在糖尿病肾病发病机制中作用的研究进展

黎池健，黄玉香，许伟成，钱　格，李永强*

(南方医科大学第三附属医院，广州 510500)

摘　要：摘　要：糖尿病肾病是目前终末期肾脏疾病的主要原因，给患者家庭及社会带来沉重负担，如何预防及治疗糖尿病肾病成为亟需解决的问题。然而，糖尿病肾病的发病机制极其复杂，其中mTOR 信号通路在其中扮演着重要角色。该综述主要总结了mTOR 信号通路对糖尿病肾病的影响并阐述其可能存在的机制，希望能够给予同行些许借鉴。

The advances of mTOR signal pathway in diabetes kidney disease

LI Chi-Jian， HUANG Yu-Xiang， XU Wei-Cheng， QIAN Ge， LI Yong-Qiang*

(The Third Affiliated Hosptial of Southern Medical University， Guangzhou 510500， China)

Abstract: Abstract: Diabetic nephropathy， one of the main causes of end-stage renal disease， not only brings a heavy burden to a family， but also becomes a big prolem to society nowadays. Preventing and curing the disease have become an urgent problem to be solved. However， the pathogenesis of diabetes kidney disease is so complex that it is extremely hard to deal with， in which mTOR signaling pathway plays an important role. This review mainly summarizes the effect of mTOR signal pathway on diabetes kidney disease and elaborates the possible mechanism， hoping to give some reference to the peers.