《生命科学》 2019, 31(3): 279-283

急性肾损伤向慢性肾脏病转变的机制研究进展

赵晓庆，乔　晞*

(山西医科大学第二临床医学院，太原 030001)

摘　要：摘　要：急性肾损伤(AKI) 是慢性肾病(CKD) 和终末期肾病发生发展的危险因素。AKI 后，即使肾功能完全恢复，仍可能遗留肾脏结构的异常，进而发展为CKD。AKI 转变为CKD 的机制复杂，目前尚不完全清楚，有多种机制介导，包括肾小管上皮细胞修复障碍和细胞周期停滞、内皮细胞的损伤和微循环血管床减少、慢性炎症反应、线粒体功能障碍、肾素- 血管紧张素系统活化、表观遗传改变、组织与细胞衰老等，最终均可导致或加重肾脏纤维化，造成CKD。该文就AKI 转变为CKD 的机制进行综述。

Mechanisms of acute kidney injury to chronic kidney disease transition

ZHAO Xiao-Qing， QIAO Xi*

(Second Medical College of Shanxi Medical University， Taiyuan 030001， China)

Abstract: Abstract: Acute kidney injury (AKI) is a risk factor for the future development of chronic kidney disease (CKD)and end-stage renal disease (ESRD). After AKI， even if the renal function is completely recovered， the abnormal structure of the kidney may be remained. Mechanisms of AKI-to-CKD transition are complex， including renal tubular epithelial cell repair disorder and cell cycle arrest， endothelial cell damage and microcirculation vascular bed reduction， chronic inflammation， mitochondrial dysfunction， tissue and cellular senescence. The precise mechanisms are not completely understood. The article summarized the main mechanisms for CKD progression following AKI.