《生命科学》 2019, 31(3): 270-278
摘 要：摘 要：热休克蛋白是一类广泛存在于原核生物和真核生物体内且结构上高度保守的蛋白质。有机体在应激条件下，为克服压力会诱导其表达，因此，热休克蛋白又被称为应激蛋白。作为进化上最保守的蛋白质之一，热休克蛋白70 (heat shock protein 70， Hsp70) 是生物细胞中含量最高的一种热休克蛋白，可诱导性最强，具有多种生物学功能，因此，又被称为主要热休克蛋白。由于蛋白质是细胞重要成分之一，几乎涉及所有的生物学过程，Hsp70 家族成员控制着细胞蛋白质稳态的所有方面，因此，Hsp70 一直是科学研究的热点之一。该文概括了近年来Hsp70 的生物学功能和作用机制研究进展，并对该领域的研究进行了展望。
Abstract: Abstract: Heat shock proteins widely exist in the prokaryotic and eukaryotic organisms， the structure of which are always highly conservative. They are also known as stress proteins， which are induced owing to the response of organism upon stress condition. As one of the most evolutionarily conserved proteins， heat shock proteins 70(Hsp70) is the most abundant heat shock protein with the strongest inducibility and many biological functions in cells. It is thus also called the main heat shock protein. As one of the main components in cells， protein is involved in almost all kinds of biological processes. Hsp70 family members control all aspects of cellular protein homeostasis， and hence Hsp70 is one of hot topics in researches all the time. The recent studies related to the biological functions and molecular mechanisms of Hsp70 were summarized here， the future prospective is also presented.
