《生命科学》 2019, 31(3): 217-224
摘 要：摘 要：肿瘤相关巨噬细胞(tumor-associated macrophages， TAMs) 在肿瘤微环境中扮演着重要的角色，TAMs 的大量存在与不良预后密切相关。近年来，TAMs 的相关问题成为研究的热点，该文就TAMs 的募集、TAMs 的极化状态及TAMs 与肿瘤之间的相互作用问题进行了综述。该文对经典活化的M1 型和替代活化的M2 型巨噬细胞对肿瘤影响研究的最新进展进行了总结。此外，对TAMs 的多种靶向治疗策略进行了总结和讨论。这些治疗策略中包含抑制TAMs 的募集、直接清除TAMs、将M2 型TAMs 极化为M1 型TAMs以及提高TAMs 的吞噬能力等方法和手段。这些研究有助于深入理解TAMs 与肿瘤相互作用的机理，并为肿瘤的联合治疗提供借鉴和参考。
Abstract: Abstract: Tumor-associated macrophages (TAMs) in microenvironment mediate many important biological functions in tumor progress. The abundance of TAMs in tumor is usually correlated with a worse patient prognosis. Significant attention has been drawn towards development of TAMs in recent years. In this paper， we discuss the recruitment of TAMs， two main kinds of polarization states and the interaction between TAMs and tumors respectively. Recent advances in the study of classically activated M1 and alternative activated M2 macrophages are summarized. In addition， a variety of targeted treatment strategies for TAMs are discussed. These therapeutic strategies include inhibition of TAMs recruitment， direct depletion of M2 TAMs， repolarization of M2 TAMs to Ml macrophages and enhancement of macrophage-mediated tumor cell killing or phagocytosis. The results of these
studies may improve the understanding about the mechanism of TAMs-tumor interaction and provide inspiration for the combined treatment of tumor.
