摘 要：摘 要：药物基因组学的研究任务是阐明个体差异的遗传基础，并利用这些遗传信息来预测药物的疗效、毒性和安全性。绝大多数的癌症化疗药物在治疗效果及正常组织毒性上的个体差异一直广为关注。不仅诸多临床因素(如年龄、性别、饮食、药物相互作用等)与药物反应和治疗效果有关，而且药物分布(转运和代谢)和药物靶标的遗传变异同样可导致癌症治疗上的差异。本篇综述主要讨论当前和将来药物基因组学在临床癌症治疗和抗癌药物研制方面的应用。
关键词：药物基因组学；遗传变异；癌症治疗；抗癌药物研发
Abstract: Abstract: Pharmacogenomic studies aim to elucidate the genetic bases for interindividual differences and to use such genetic information to predict the safety, toxicity, and/or efficacy of drugs. Interindividual differences in tumor response and normal tissue toxicities are consistently observed with most chemotherapeutic agents or regimens. While many clinical variables have been associated with drug responses (e.g., age, gender, diet, drug-drug interactions), inherited variations in drug disposition (transport and metabolism) genes and drug target genes also likely contribute to the observed variability in treatment outcome. This review discusses the current and future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
Key words: pharmacogenomics; genetic variations; cancer therapy; cancer drug development
