《生命科学》 2019, 31(2): 201-208

小檗碱调节糖脂代谢及其抗糖尿病活性的研究

李东伟1，2，3*，邵梦寒1，葛传慧1，2，周　忍1，2，丁晨宵1，于立恒4，陈德宇1，2

(1 阜阳师范学院生物与食品工程学院，阜阳 236037；2 抗衰老中草药安徽省工程技术研究中心，阜阳 236037；3 阜阳师范学院保护生物学研究中心，阜阳 236037；4 阜阳市人民医院中西医结合科，阜阳 236000)

摘　要：摘　要：小檗碱(berberine， BBR) 是中药黄连的主要活性成分，属于异喹啉类生物碱，具有广谱抗菌作用。近年来发现它还有降血糖、降血脂、免疫调节及改善充血性心力衰竭等药理作用。研究表明，BBR 能够改善糖尿病相关疾病的症状，且作用广泛，不仅可影响编码基因的表达，还与miRNA 和lncRNA 等非编码基因关系密切，涉及糖脂代谢、肠道菌群等多个方面。该文拟就BBR 调节糖脂代谢及其抗糖尿病活性的研究进展做一综述。

Study of berberine regulating gene expression of glucolipid metabolism and its anti-diabetic activities

LI Dong-Wei1，2，3*， SHAO Meng-Han1， GE Chuan-Hui1，2， ZHOU Ren1，2， DING Chen-Xiao1， YU Li-Heng4， CHEN De-Yu1，2

(1 School of Food and Biological Engineering， Fuyang Normal College， Fuyang 236037， China; 2 Anhui Province Anti-aging Chinese Herbal Medicine Engineering Technology Research Center， Fuyang 236037， China; 3 Conservation Biology Research Center， Fuyang Normal College， Fuyang 236037， China; 4 Department of Integrated Chinese and Western Medicine， Fuyang People's Hospital， Fuyang 236000， China)

Abstract: Abstract: Berberine (BBR) is an isoquinoline alkaloid originally isolated from Chinese herb Coptis chinensis Franch (Huanglian)， which has a broad-spectrum antibacterial effect as the main active ingredient of R. coptidis. Recently， it has been found that it has the pharmacological effects of lowering blood glucose， reducing blood lipid， regulating immunity and improving the symptom of congestive heart failure， etc. But the mechanisms remain to be studied. Previous researches show that BBR may improve the symptoms of type 2 diabetes (T2D) and its complications， and then exert global anti-diabetic effects by regulating a few coding genes， but also noncoding RNAs， such as miRNAs and lncRNAs. In this paper， the research progress of BBR regulating genes expression on glucolipid metabolism and its anti-diabetic activities was reviewed.