《生命科学》 2019, 31(2): 195-200

细胞自噬与非小细胞肺癌的研究进展

何　艳，郑立敏，龚雪巍，盛德乔*

(三峡大学医学院，肿瘤微环境与免疫治疗湖北省重点实验室， 宜昌 443002)

摘　要：摘　要：自噬不仅与NSCLC 的增殖、侵袭及转移密切相关，而且在抗肿瘤药物介导的细胞死亡中发挥重要作用，因此，研发以自噬为靶点的药物可能是人类疾病治疗应用的新趋势。多种信号通路参与了细胞自噬的调控，明确细胞自噬的调控机制能为NSCLC 的靶向治疗提供新思路。

Progress in the study of autophagy and non-small lung cancer

HE Yan， ZHENG Li-Min， GONG Xue-Wei， SHENG De-Qiao*

(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy， College of Medical Science of China Three Gorges University， Yichang 443002， China)

Abstract: Abstract: Autophagy is not only closely related to proliferation， invasion and metastasis of NSCLC， but also plays an important role in anti-tumor drug-mediated cell death. Thus， the development of drugs targeting autophagy may be a new trend in the treatment of human diseases. Various signaling pathways have been involved in the regulation of autophagy， and clarifying regulation mechanism of cell autophagy can provide new ideas for targeted therapy of NSCLC.