《生命科学》 2019, 31(2): 190-194

巨噬细胞极化与胰腺炎症及纤维化的相关研究进展

辛嘉萁，许小凡，张　红*

(陕西中医药大学基础医学院，西安 712046)
    

摘　要：摘　要：巨噬细胞与胰腺炎症的发生和发展有密切的联系，但其作用机制目前仍不清楚。近年来的研究提示，不同极化类型的巨噬细胞在胰腺炎症及胰腺纤维化的进展中可能发挥着不同的作用。探究不同极化类型的巨噬细胞在胰腺炎症及胰腺纤维化中的作用，将为该疾病的防治提供新的治疗思路。

New insight into macrophage polarization in the development of pancreatic inflammation and fibrosis

XIN Jia-Qi， XU Xiao-Fan， ZHANG-Hong*

(Basic Medicine Department of Shaanxi University of Chinese Medicine， Xi’an 712046， China)

Abstract: Abstract: Macrophage is closely related to the progression of pancreatitis， but its potential mechanisms remain elusive. Increasing evidence has shown that different phenotype of macrophages may play a different role in the development of pancreatitis and pancreatic fibrosis. This review focused on the advanced researches on the relationship between different phenotype of macrophages and pancreatitis.