(1 武汉大学人民医院检验医学中心,武汉 430060;2 武汉大学中南医院检验科,基因诊断中心,武汉 430071)

摘 要:摘 要:N6- 甲基腺嘌呤(m6A) 是发生于哺乳动物mRNA 中最为常见的修饰方式,参与mRNA 的剪切、翻译和降解,影响基因的表达。近年来,m6A 修饰及其调控蛋白在肿瘤发生发展中的作用已成为生物医学研究的热点领域之一。现从人体器官系统角度,对m6A 修饰及其调控蛋白在多种肿瘤进程中的作用以及分子机制进行综述。

The role of N6-methyladenosine modification in mRNA in clinical cancers
HUANG Jing-Tao1,2, LIU Song-Mei2*
(1 Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China; 2 Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China)

Abstract: Abstract: N6-methyladenosine (m6A) is the most common modification in mRNA, which mainly occurs in 3'-UTR region or near stop codon. As an important epigenetic modification, m6A regulates mRNA stability, splicing and translation to control gene functions. Recently, the regulatory functions of m6A and its machinery proteins in tumorigenesis have become the hot research area. This review summarized the roles of m6A in different clinical cancers according to human system organs.

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