《生命科学》 2019, 31(2): 143-152
摘 要：摘 要：Angiomotin (AMOT) 是一种血管抑制素结合蛋白，AMOT 在血管内皮细胞的迁移、紧密连接和管状形成等方面起着重要调控作用。AMOT 及其同源家族蛋白AMOTL1 和AMOTL2 可能与Hippo 信号通路的下游效应分子YAP 相互作用来参与调控肿瘤细胞的生长。在乳腺癌、前列腺癌等癌症中，AMOT 能够增加 YAP 进入细胞核的水平从而促进癌细胞的增殖和迁移；但在胶质母细胞瘤、肺癌等癌细胞中，AMOT 将YAP 滞留在细胞质或紧密连接处，从而抑制YAP 的活性。另外，AMOT 也可以促进Hippo 信号通路中核心激酶LATS 来发挥抑制肿瘤细胞增殖的作用。AMOT 在肿瘤细胞生长中发挥的不同作用还需要更深入的研究，现对AMOT 在癌症中的调控作用及在Hippo 信号通路中的调控机制等方面的研究进展进行综述。
Abstract: Abstract: Angiomotin (AMOT) identified as angiostatin binding protein， and it plays an important role in the regulation of endothelial cell migration， tight junction and blood vessel formation. AMOT and its homologues AMOTL1 and AMOTL2 may interact with YAP， a downstream effector of Hippo pathway， to regulate the growth of tumor cells. AMOT could increase the level of YAP into the nucleus to promote the proliferation and progression of cancer cells such as breast cancer， prostate cancer. On the other hands， AMOT could delay YAP into the cytoplasm which could inhibits the growth of tumor cells such as glioblastoma and lung cancer. In addition， AMOT can also promote the core kinase LATS in Hippo pathway to inhibit the proliferation of tumor cells. The different roles of AMOT in the growth of tumor cells need to be further studied. This article mainly reviews the research progress in the regulation of AMOT in cancer and the regulation mechanism of Hippo pathway in cancer.
