《生命科学》 2006, 18(1):

NKT细胞在抗肿瘤免疫中的作用及其机制

杨　洁^1,2，范华骅^1*，章　平²，高　峰¹

1上海市血液中心血液工程研究室，上海 200051； 2华东师范大学生命科学学院分子免疫研究室，上海 200062

摘　要：摘　要：NKT细胞是免疫细胞中一类具有NK细胞特定标志的T细胞亚群，经活化，既可直接作为抗肿瘤效应细胞发挥杀伤作用，又能通过激活其他免疫效应细胞，如NK细胞，间接实现抗肿瘤作用。NKT细胞在抗肿瘤免疫、获得性免疫应答及免疫调节中起着重要作用。
关键词：NKT细胞；抗肿瘤作用；抗肿瘤机制

Functional role of natural killer T cells and their mechanisms in anti-tumor immunity

YANG Jie^1,2, FAN Hua-Hua^1*, ZHANG Ping²,GAO Feng¹

1 Shanghai (Red cross) Blood Center,Laboratory for Blood Engineering, Shanghai 200051, China; 2 Laboratory of Immunology, School of Life Sciences, East China Normal University, Shanghai 200062, China

Abstract: Abstract: Natural killer T (NKT) cells are a population of T cells that share some characteristics with natural killer (NK) cells. After activated, NKT cells can kill tumors directly as the anti-tumor effectors and they can also activate other cell types, such as NK cells, to mediate anti-tumor effects indirectly. NKT cells play an important role in anti-tumor immunity, adaptive immune responses and immunoregulation.
Key Words: NKT cells; anti-tumor function; anti-tumor mechanism