《生命科学》 2019, 31(2): 135-142

mTOR信号通路在疾病中的作用与调控机制

姚睿原1，魏鸿渊2，雷金叶2，王志钢1*

(1 内蒙古大学生命科学学院，呼和浩特 010021；2 临河区人民医院检验科，巴彦淖尔 015000)

摘　要：摘　要：mTOR 是一种丝氨酸/ 苏氨酸蛋白激酶，与不同的蛋白质结合形成mTORC1 和mTORC2 两种复合物，体现了结构和功能上的差异。mTOR 信号通路参与多种生理和病理过程，不仅可以调节细胞生长、代谢、血管生成、内环境稳定、自噬和衰老等生理过程，还与多种恶性肿瘤、自身免疫性疾病、心脑血管疾病等一系列的疾病发生及肿瘤抗药性相关。该文综述了mTOR 信号通路在疾病发生中的作用及调控机制，为疾病治疗提供参考。

Progress on the role of mTOR signaling pathway in the pathogenesis and regulatory mechanisms

YAO Rui-Yuan1， WEI Hong-Yuan2， LEI Jin-Ye2， WANG Zhi-Gang1*

(1 College of Life Sciences， Inner Mongolia University， Hohhot 010021， China;
    2 Clinical Laboratory， Linhe People's Hospital， Bayanur 015000， China)

Abstract: Abstract: mTOR is a conserved serine/threonine kinase that is known to be part of two different protein complexes: mTORC1 and mTORC2， which differ in some components and in upstream and downstream signaling. mTOR signaling pathway was associated with multiple physiological and pathological processes， and it not only plays a significant role in cell growth， metabolism， homeostasis， autophagy and aging， but also is involved in human diseases including cancer， autoimmune diseases， cardiovascular diseases and cancer resistance. The role of mTOR signaling pathway in the occurrence of diseases was reviewed， aiming to provide references for disease therapy.