《生命科学》 2019, 31(1): 106-110

α-Klotho的作用及其与运动/体力活动的关系

李安康，左　群*

(上海体育学院运动科学学院，上海 200438)

摘　要：摘　要：Klotho 是一种抗衰老基因，具有调节代谢稳态、抗氧化应激和细胞凋亡、保护血管内皮、预防和改善心血管疾病及肾脏疾病等作用。运动/ 体力活动的抗衰老及改善疾病的作用已被大量研究所证明。Klotho 和运动/ 体力活动对衰老及衰老相关疾病的调控存在许多重叠之处，两者之间是否有相关性，其可能存在哪些机制，现就这些研究做一综述。

The role of α-Klotho and its relationship with exercise/physical activity

LI An-Kang， ZUO Qun*

(School of Sports Science， Shanghai University of Sport， Shanghai 200438， China)

Abstract: Abstract: Klotho is an anti-aging gene that regulates metabolic homeostasis， antioxidant stress and cell apoptosis， protects vascular endothelium， prevents and improves cardiovascular and renal diseases. The role of exercise/physical activity in anti-aging and improving the disease has been demonstrated by numerous studies. There are many overlaps between Klotho and exercise/physical activity on the regulation of aging and aging-related diseases. Are there any correlations between them， and what are the possible mechanisms? This article reviews these studies.