《生命科学》 2019, 31(1): 99-105
摘 要：摘 要：中性粒细胞明胶酶相关脂质运载蛋白(NGAL) 作为载脂蛋白家族的新成员，通过调节肾间充质细胞向肾小管上皮细胞转化、抑制肾脏纤维化、清除氧自由基参与肾脏的损伤修复。国内外研究报道，揭示了在急性肾损伤(AKI) 及慢性肾脏病(CKD) 等多种肾脏疾病发生发展中，在传统肾功能指标变化之前，尿液及血液中即可检测到NGAL 浓度的变化，可见通过检测NGAL 浓度对多种肾脏疾病的早期诊断、治疗及预后具有重要意义。
Abstract: Abstract: Neutrophil gelatinase-associated lipocalin (NGAL)， a novel member of the apolipoprotein family， can participate in the repair of kidney damage by means of regulating the transformation of renal mesenchymal cells into renal tubular epithelial cells， inhibiting kidney fibrosis， and clearing oxygen free radicals. Studies in the domestic and abroad have revealed that during the initiation and development of kidney disease such as acute kindey injury (AKI) and chronic kidney disease (CKD)， changes in NGAL levels can be detected in urine and blood before the change of traditional renal function index. It can be seen that the detection of changes in NGAL concentration is of great significance for the early diagnosis， treatment and prognosis of multiple kidney diseases. The biological characteristics of NGAL and its relationship with kidney disease are reviewed.
