《生命科学》 2019, 31(1): 87-92

DNA甲基转移酶与肿瘤关系的研究进展

肖　枭，王艳林，黄利鸣*

(三峡大学医学院，肿瘤微环境与免疫治疗湖北省重点实验室，宜昌 443002)

摘　要：摘　要：DNA 甲基化修饰在基因的表观遗传调控中发挥重要作用，而DNA 甲基转移酶(DNMT) 为DNA甲基化模式建立和维持所必需。哺乳动物细胞主要含3 种DNMT，DNMT1 的主要功能是维持甲基化，DNMT3a 和DNMT3b 则催化DNA 的从头甲基化。DNMT 活性与功能改变导致的基因表达异常与多种肿瘤的发生和发展密切相关，由此成为肿瘤治疗和新型抗肿瘤药物研发的重要分子靶点。

Research progress on relationship between DNA methyltransferases and tumors

XIAO Xiao， WANG Yan-Lin， HUANG Li-Ming*

(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy， Medical College of China Three Gorges University， Yichang 443002， China)

Abstract: Abstract: DNA methylation plays an important role in the epigenetic regulation of genes， while DNA methyltransferase (DNMT) is necessary for the establishment and maintenance of DNA methylation pattern. Mammalian cells mainly contain three kinds of DNMT. The main function of DNMT1 is to maintain methylation status of DNA， while DNMT3a and DNMT3b catalyze de novo methylation of DNA. The abnormal gene expression caused by the change of activity and function of DNMTs is closely related to the occurrence and development of various tumors，making DNMTs an important molecular target for the tumor therapy and the development of new antitumor drugs. This paper gave a brief overview of the research progress in this field.