《生命科学》 2019, 31(1): 67-73

自噬与骨质疏松

郭健民1，2，周　林1，章　岚1*

(1 山东体育学院研究生教育学院，济南 250102；2 上海体育学院运动科学学院，上海 200438)

摘　要：摘　要：自噬是一个清除受损细胞成分或老化蛋白质的过程，并以此参与不同细胞的保护。骨质疏松与衰老相关，其主要特征是骨形成受抑制而骨吸收增加，使骨转换增加。在老年阶段，无论是男性还是女性，都会出现骨量和骨强度的下降，从而使骨折的发生率增加。临床研究和动物实验都证明，衰老导致的骨量丢失与自噬的累积、活性氧水平增加、雌激素缺乏和高水平的内源性糖皮质激素等因素相关联。越来越多的研究表明，衰老相关的因素参与调控自噬，并在骨重塑以及衰老引起的骨量丢失和骨强度下降中发挥重要的调控作用。现通过综述自噬与骨代谢的相关文献，旨在阐明自噬对骨质疏松的调控机制。

The role of autophagy in osteoporosis

GUO Jian-Min1，2， ZHOU Lin1， ZHANG Lan1*

(1 College of Graduate Education， Shandong University of Sport， Jinan 250102， China;
    2 School of Kinesiology， Shanghai University of Sport， Shanghai 200438， China)

Abstract: Abstract: Autophagy is a process that removes damaged cellular components or aged proteins and participates in the protection of different cells. Osteoporosis is associated with aging， and its main features are inhibition of bone formation and increased bone resorption， thereby increasing bone turnover. In the elderly， both male and female will have a decrease in bone mass and bone strength， which increases the incidence of fractures. Both clinical studies and animal experiments have demonstrated that loss of bone mass due to aging is associated with accumulation of autophagy， increased levels of reactive oxygen species， sex hormone deficiency， and high levels of endogenous glucocorticoids. A growing number of studies have shown that aging-related factors are involved in the regulation of autophagy and play a regulatory role in bone remodeling， loss of bone mass and bone strength caused by aging. This article provided a theoretical basis for the treatment and prevention of osteoporosis by reviewing the mechanisms of bone metabolism associated with aging and autophagy.