《生命科学》 2019, 31(1): 55-60

非编码RNA与肺纤维化的相关研究进展

黄明华，曾林祥*

(南昌大学第二附属医院呼吸与危重症医学科，南昌 330006)

摘　要：摘　要：肺纤维化(pulmonary fibrosis， PF) 是一种慢性进行性的肺间质损伤性疾病，其发病机制复杂，确诊后中位生存期短，目前缺乏确切有效的治疗方法。因此，明确 PF 的发病机制对于寻找有效的治疗靶点十分重要。非编码RNA (noncoding RNA， ncRNA) 是从基因组中转录而来，不编码蛋白质的RNA。近几年来，研究者们发现，ncRNA 在机体多种生物学过程中发挥了重要调控作用，并对其日益重视。已有许多研究表明，ncRNA 在PF 的发生发展中具有重要作用。现就近年来关于ncRNA 在PF 中的研究进展以及未来通过干预相关ncRNA 来治疗PF 的前景及挑战作一综述。

Research progress of non-coding RNA in pulmonary fibrosis

HUANG Ming-Hua， ZENG Lin-Xiang*

(Department of Respiratory and Critical Care Medicine， The Second Affiliated Hospital of Nanchang University， Nanchang 330006， China)

Abstract: Abstract: Pulmonary fibrosis (PF) is a chronic and progressive pulmonary interstitial injury disease. The median survival time after diagnosis is short. Its pathogenesis is complex. At present， there is no definite and effective treatment. Therefore， it is very important to clarify the pathogenesis of PF for finding effective therapeutic targets. Noncoding RNA (ncRNA) is transcribed from the genome， but does not encode protein. In recent years， researchers have discovered that ncRNAs play an important role in regulating a variety of biological processes and attach more importance to them. Many studies have shown that ncRNA plays an important role in the development of PF. This article reviews the recent researches on ncRNA in PF and the future prospects and challenges of treating PF by intervening with related ncRNAs.