《生命科学》 2019, 31(1): 49-54

RNA修饰对长链非编码RNA的调控作用

马文博，颜景斌*

(上海市儿童医院，上海医学遗传研究所，上海交通大学附属儿童医院，国家卫健委
    胚胎分子生物学重点实验室，上海市胚胎与生殖工程重点实验室，上海 200040)

摘　要：摘　要：长链非编码RNA (lncRNA) 能在表观遗传、转录以及转录后水平上调控基因表达，与疾病的发生、发展和防治有着密切的联系。RNA 修饰介导的表观转录组学调控是表观遗传的新领域，可以在转录后水平调控基因表达，并且可以作为一种重要的修饰手段对lncRNA 进行调控。RNA 修饰可以通过对lncRNA 表达水平、剪切方式及二级结构的调控，影响各种生物学进程。现回顾和展望RNA 修饰对lncRNA 的调控作用和其潜在的生物学功能。

Regulation of RNA modification on long noncoding RNA

MA Wen-Bo， YAN Jing-Bin*

(Shanghai Key Laboratory of Embryo and Reproduction Engineering， Key Laboratory of Embryo Molecular Biology of National Health Commission， Shanghai Institute of Medical Genetics， Shanghai Chlidren’s Hospital， Shanghai JiaoTong
    University， Shanghai 200040， China)

Abstract: Abstract: With the ability to regulate the gene expression in epigenetic， transcriptional or/and post-transcriptional manners， long non-coding RNA (lncRNA) is closely associated with occurrence， development and treatment of some diseases. As a new field， epigenetic transcriptomics through RNA modification could influence gene expression in post-transcriptional manner， which is an important modification to regulate lncRNA. Through regulating the expression， splicing and secondary structure of lncRNA， RNA modification is capable of affecting various biological processes. In this paper， we will review and prospect the regulatory effects of RNA modification on lncRNA and its potential biological functions.