《生命科学》 2019, 31(1): 44-48

肿瘤相关中性粒细胞促进肿瘤过程中细胞因子影响作用的研究进展

李程豪1，2，王厚明1*，骆亚莉2，刘永琦2

(1 重庆市铜梁区人民医院，重庆 402560；2 甘肃中医药大学，甘肃省高校重大疾病分子医学与中医药防治研究省级重点实验室，兰州 730000)

摘　要：摘　要：肿瘤微环境中的中性粒细胞作为主要的肿瘤浸润性髓系细胞，在肿瘤生长和恶性转化中起着重要作用。近期研究证明，肿瘤相关中性粒细胞通过促进肿瘤生长、转移、血管生成及免疫抑制等途径影响肿瘤发展，并且细胞因子在其中各个阶段均发挥了关键作用。现从细胞因子的角度对肿瘤相关中性粒细胞促进肿瘤作用途径及机制的研究进展进行综述，为肿瘤防治研究提供新的思路。

The research progress on the role of cytokines in tumor-associated neutrophils promoting tumorigenesis and progression

LI Cheng-Hao1，2， WANG Hou-Ming1*， LUO Ya-Li2， LIU Yong-Qi2

(1 The People's Hospital of Tongliang District Chongqing City， Chongqing 402560， China; 2 Gansu Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research， Gansu University of Chinese Medicine， Lanzhou 730000， China)

Abstract: Abstract: In the tumor microenvironment， as the primary tumor-infiltrating myeloid cells， neutrophils play a major role in growth and malignant progression of tumor. Previous studies indicated that tumor-associated neutrophils had influences on promoting the proliferation of tumor cells， accelerating growth and metastasis of tumor， promoting angiogenesis and immunosuppression. And the related cytokines play a quite important role in the aforesaid process. In this paper， we reviewed the research progress on the function and mechanism of related cytokines which have effect on neutrophils promoting tumor growth and transfer.