《生命科学》 2019, 31(1): 35-43

细胞因子对类风湿性关节炎骨平衡的调节作用

杨　林1，吕　丹1，沈小芳1，张安兵2，肖　娟1*

(1 湖北文理学院分子医学实验室，襄阳 441053；2 湖北文理学院附属襄阳市中心医院风湿免疫科，襄阳 441021)

摘　要：摘　要：类风湿性关节炎(rheumatoid arthritis， RA) 是一种以滑膜持续炎症和关节软骨及骨质破坏为特征的自身免疫性疾病。RA 的发展伴随着滑膜细胞增生、新生血管、局部大量炎性细胞浸润及细胞因子水平的失调。异常炎症反应贯穿RA 始终，细胞因子失调引起的骨破坏和骨建之间的失衡导致RA 关节炎症和骨质破坏。RA 致残率极高，且没有根治方法对其进行早期诊断和治疗，延缓骨损伤尤为重要。目前临床常用的诊断指标缺乏特异性。现以细胞因子为切入点，概述其在RA 不同时期的不同存在及对RA 骨平衡的调控作用机制，为寻找RA 更加精准的早期诊断指标和治疗靶点提供线索。

The effect of cytokines on the balance between osteoclastogenesis and    osteoblastogenesis in rheumatoid arthritis

YANG Lin1， LV Dan1， SHEN Xiao-Fang1， ZHANG An-Bing2， XIAO Juan1*

(1 Department of Molecular Medicine Laboratory， Hubei University of Arts and Science， Xiangyang 441053， China; 2 Department of Rheumatism and Immunology， Xiangyang Central Hospital， Hubei University of Arts and Science，
    Xiangyang 441021， China)

Abstract: Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by constant synovium inflammation， cartilage degradation and bone resorption. RA develops with the formation of pannus， which consists of synovium hyperplasia， microangiogenesis， inflammatory cells infiltration and aberrant cytokine level. Given that RA is an autoimmune disease， abnormal inflammatory reaction is present during the whole course. The cytokinerelated imbalance between osteoclastogenesis and osteoblastogenesis leads to synovitis and ultimately， bone damage. Due to the high risk of irretrievable disability， it is essential to give early diagnosis and treatment. Due to the fact that serological indexes used now lack specificity， it is suggested cytokines be an entry point. Probing their presence at different phases of RA and how they cause the imbalance mentioned above is responsible for when and how to give more precise diagnosis and medication to RA patients with clinical manifestation.