摘 要：摘 要：Stargazin是一种主要在小脑颗粒神经元中表达的电压依赖钙离子通道的γ-2亚基，在结构上是一种四跨膜蛋白。功能研究表明stargazin有双重作用，一方面可以调节谷氨酸受体质膜运输和突触定位；另一方面还可以影响这些受体的生物物理特性。这些研究阐明了神经系统突触反应调节的复杂性，同时也为应用奠定了基础。
关键词：stargazin；谷氨酸受体；受体运输；受体门控
Abstract: Abstract: Stargazin is a voltage-dependent calcium channel g-2 subunit which mainly expressed in cerebellar granule cells and is a four-transmembrane protein. Functional researches suggest stargazin has a dual role,which is a regulator of AMPA receptors (AMPARs) trafficking to the plasma membrane and targeting to the synapses,and influences the biophysical properties of AMPARs also.These researches illuminate regulated complexity of synaptic responses in the nervous system,lay a foundation for application.
Key words: stargazin; AMPAR;receptor trafficking; receptor gating
