《生命科学》 2018, 30(11): 1252-1257

长链非编码RNA CCAT2与癌症

莫　娇1，2#，李子涵1#，于水灵1，2，夏　磊1，2，杨玉容1，2，谢伟全1*，涂　剑1*

(1 南华大学药物药理研究所，衡阳 421001；2 南华大学医学研究中心，衡阳 421001)

摘　要：摘　要：长链非编码RNA (lncRNA) 与癌症的发生发展密切相关。结肠癌相关转录因子(CCAT) 2 是2013 年鉴定的一种新的lncRNA，已发现其在结直肠癌、肝癌、乳腺癌以及胃癌等多种癌细胞中表达异常升高，通过Wnt、PI3K/AKT/mTOR 和GSK3β/β-catenin 等信号通路形成复杂的癌症调控网络，在癌症的增殖、侵袭/转移和细胞凋亡等过程中发挥着重要的作用，提示CCAT2 有望成为癌症诊断与治疗的新的分子靶点。现综合近年来CCAT2 在癌症中的研究进展作一综述。

Long non-coding RNA CCAT2 and cancer

MO Jiao1，2#， LI Zi-Han1#， YU Shui-Ling1，2， XIA Lei1，2， YANG Yu-Rong1，2， XIE Wei-Quan1*， TU Jian1*

(1 Institute of Pharmacy and Pharmacology， University of South China， Hengyang 421001， China; 2 Medical Experimental Research Center， University of South China， Hengyang 421001， China)

Abstract: Abstract: Long non-coding RNA (lncRNA) has close relationship with the development of human cancer. Colon cancer associated transcription factor (CCAT) 2， a newly identified member of many lncRNAs in 2013， has been found to be up-regulated in various cancers such as colorectal， liver， breast and gastric cancer. It not only develops a complicated network of cancer controlled under the signaling pathways like Wnt， PI3K/AKT/mTOR and GSK3β/β-catenin， but also plays an important role in cell proliferation， invasion/metastasis and cell apoptosis. All above suggests CCAT2 could be expected to become a new target for the diagnosis and treatment of cancer. Therefore， this paper summarizes the research progress of CCAT2 with cancer in recent years.