《生命科学》 2018, 30(11): 1244-1251

细菌间blaNDM-1传播规律的研究进展

喻浠明，李　畅，张文慧，贾　宇*，张林波*

(吉林农业大学生命科学学院病原微生物与免疫学研究室，长春 130118)

摘　要：摘　要：新德里金属β- 内酰胺酶-1 (New Delhi metallo-β-lactamase 1， NDM-1) 导致革兰氏阴性细菌对几乎所有的β- 内酰胺类抗生素(β-lactam antibiotic) 产生抗性。携带NDM-1 编码基因(blaNDM-1) 的肠杆菌科(Enterobacteriaceae) 和不动杆菌属(Acinetobacter spp.) 细菌在世界各地广泛流行，严重威胁着公共健康。现对NDM-1 的结构、突变亚型和传播规律进行综述，为预防和控制NDM-1 携带菌提供策略。

Research progress in dissemination of blaNDM-1 between bacteria

YU Xi-Ming， LI Chang， ZHANG Wen-Hui， JIA Yu*， ZHANG Lin-Bo*

(Laboratory of Pathogenic Microbiology and Immunology， College of Life Science，
    Jilin Agricultural University， Changchun 130118， China)

Abstract: Abstract: The New Delhi metallo-β-lactamase 1 (NDM-1) producing Gram-negative bacteria are resistant to almost all the β-lactam antibiotics. Enterobacteriaceae and Acinetobacter spp. carrying blaNDM-1 have disseminated globally and been a serious threat to public health. This paper briefly reviews the structure， variants and spread of NDM-1， and provides strategies to prevent and control the dissemination of NDM-1-positive bacteria.