《生命科学》 2018, 30(11): 1184-1192

植物1型酪蛋白激酶的研究进展及展望

陈虎辉1，薛红卫2*

(1 中山大学生命科学学院国家生物防治重点实验室和广东省植物资源利用重点实验室，广州 510275； 2 中国科学院上海植物生理生态研究所植物分子遗传国家重点实验室，上海 200032)

摘　要：摘　要：1 型酪蛋白激酶(casein kinase 1， CK1) 是一种在动植物和微生物中普遍存在的蛋白激酶。CK1 通过对底物蛋白序列中的丝氨酸/ 苏氨酸进行磷酸化，从而调控底物蛋白的活性、稳定性等。在动物和微生物中的研究证明，CK1 参与了生物体许多重要生理和信号过程的调控，包括生物节律、DNA 损伤修复、细胞分裂与肿瘤发生、信号调控与形态建成等。相对而言，植物CK1 的研究还较为初步。植物基因组中含有更多的CK1 成员，且有一类植物特有的PS-CK1。现综述目前植物中CK1 的研究进展，并初步探讨今后植物CK1 的研究重点。

Casein kinase 1 in plants

CHEN Hu-Hui1， XUE Hong-Wei2*

(1 National State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resource， School of Life Sciences， Sun Yat-sen University， Guangzhou 510275， China; 2 National Key Laboratory of Plant Molecular Genetics， Institute of Plant Physiology and Ecology， Chinese academy of Sciences， Shanghai 200032， China)

Abstract: Abstract: Casein kinase 1 (CK1) is conserved throughout the plants and animals. CK1 phosphorylates the substrate proteins at serine or threonine to regulate the enzyme activity and protein stability. Studies in animals and microbes have shown that CK1 plays crucial regulatory roles in multiple signal transduction pathways and many important physiological processes including biological rhythm， DNA damage repair， cell proliferation and tumorigenesis， signaling regulation and morphogenesis. However， the study of plant CK1 is relatively preliminary. Compared with animals and microbes， plants genome encodes more CK1 members， especially several plant-specific CK1 (PS-CK1). Here， we summarized the research progresses of CK1 in plants， and the important prospects of plant CK1 research
    in the future were discussed.