《生命科学》 2018, 30(11): 1165-1172

非酒精性脂肪肝发病机制和治疗的研究进展

郭　亮，汤其群*

(复旦大学“代谢与分子医学”教育部重点实验室，基础医学院生物化学与分子生物学系，上海 200032)

摘　要：摘　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease， NAFLD) 已成为全球最常见肝病之一，其发病率仍然有继续增加的趋势。NAFLD 是一类包含单纯性脂肪肝、非酒精性脂肪性肝炎(non-alcoholicsteatohepatitis， NASH) 等疾病的临床病理综合征，并可能进一步进展为肝硬化、肝衰竭和肝细胞性肝癌，威胁人类健康。目前NAFLD 的发病机制尚不完全清楚，并且尚没有理想的有效治疗药物。该文主要就NAFLD 的发病机制和治疗的研究进展进行综述，为NAFLD 的基础研究和临床治疗提供相关的参考。

Research progress of the mechanism and therapy of non-alcoholic fatty liver disease

GUO Liang， TANG Qi-Qun*

(Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education， Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences， Fudan University， Shanghai 200032， China)

Abstract: Abstract: Non-alcoholic fatty liver disease (NAFLD) has become one of the most common liver diseases throughout the world and its morbidity rate is still growing. The spectrum of NAFLD includes simple fatty liver and nonalcoholic steatohepatitis (NASH) and may progress to cirrhosis， liver failure and hepatocellular carcinoma (HCC)， posing a threat to human health. Currently， the mechanism of NAFLD pathogenesis is not fully understood and no effective drugs are available to treat NAFLD. Here， the research progress of the mechanism and therapy of NAFLD is mainly reviewed， which could provide a reference for the basic research and clinical treatments of NAFLD.