《生命科学》 2018, 30(8): 840-847

miR-29家族及其靶基因与恶性肿瘤关系的研究进展

李永懿1， 2，王鲁业1，李　平1，庄子豪1，王兆煊1，陆宇枫1，于永超1，那　嵩1，李传刚3，李墨林4*

(1 大连医科大学临床医学七年制学生，大连 116044；2 美国弗吉尼亚大学学生，夏洛茨维尔VA 22903；3 大连医科大学第二临床学院外科，大连 116023；4 大连医科大学病理生理学教研室，大连 116044)

摘　要：摘　要：微小RNA-29 (microRNA-29， miR-29) 家族成员包括miR-29a、miR-29b 和miR-29c，是一类与器官纤维化密切相关的小分子RNA。近年研究发现，多种肿瘤组织中存在miR-29s 的表达紊乱。miR-29 家族不但具有抑癌作用，还有促癌作用，其有望成为肿瘤早期诊断、疗效检测或复发监测的重要新靶标。现就miR-29s 及其靶基因在肿瘤细胞增殖、分化、凋亡、侵袭和转移中的作用及其研究进展进行综述。

Progress of miR-29 family and its target genes in tumorigenesis

LI Yong-Yi1，2， WANG Lu-Ye1， LI Ping1， ZHUANG Zi-Hao1， WANG Zhao-Xuan1， LU Yu-Feng1， YU Yong-Chao1， NA Song1， LI Chuan-Gang3， LI Mo-Lin4*

(1 Seven-year Program Medical Students， Dalian Medical University， Dalian 116044， China; 2 Student of University of Virginia， Charlottesville， VA 22903， USA; 3 Department of Surgery， The Second Affiliated Hospital， Dalian Medical University， Dalian 116023， China; 4 Department of Pathophysiology， Dalian Medical University， Dalian 116044， China)

Abstract: Abstract: microRNA-29 (miR-29) family， including miR-29a， miR-29b and miR-29c， is a group of small molecule RNA that is closely related to organ fibrosis. Accumulating studies have demonstrated that aberrant expression of miR-29s could be detected in various tumor tissues. It is thought that miR-29 serves not only as a tumor suppressor but also as a tumor promoter. It was also expected to be served as a potentially valuable tumor marker and a new target for tumor early diagnosis， progression or recurrence surveillance. The progress of miR-29 family and its target genes in tumor proliferation， differentiation， apoptosis， invasion and metastasis will be reviewed in this paper.