《生命科学》 2018, 30(7): 779-783

脂肪组织中自噬与肥胖关系的研究进展

王巍巍，邓德剑，李秋明，张喜梅*

(哈尔滨医科大学组织学与胚胎学教研室，哈尔滨 150081)

摘　要：摘　要：肥胖已成为21 世纪影响全球人类健康的主要危险因素之一，其本质之一是脂肪组织发生的慢性炎症状态。而自噬是一种分解机制，可主动降解细胞内一些物质，如衰老或失能的细胞器和大分子物质，因此自噬在改善肥胖者的脂肪组织炎症状态方面发挥着重要作用。现就自噬的基本过程及分子机制、脂肪组织中自噬与肥胖关系的研究进展作一概述。

Research progress between autophagy and obesity in adipose tissue

WANG Wei-Wei， DENG De-Jian， LI Qiu-Ming， ZHANG Xi-Mei*

(Department of Histology and Embryology， Harbin Medical University， Harbin 150081， China)

Abstract: Abstract: Obesity has become one of the major global threats of human health in the 21st century， which results from chronic inflammatory state presenting in adipose tissue. Autophagy promotes the orderly degradation of intracellular components， such as decrepit or disabled organelles and macromolecular substances， which is a conservative process playing a critical role in improving chronic inflammatory state in obese people. In this paper， we summarize the research advances on basic processes and molecular mechanisms of autophagy， and the correlation between autophagy and obesity in adipose tissue.