《生命科学》 2018, 30(7): 765-770

miR-21在非小细胞肺癌中的研究进展

龚雪巍1，郑立敏1，盛德乔1*，张利华2*

(1 三峡大学医学院，肿瘤微环境与免疫治疗湖北省重点实验室，宜昌 443002；2 三峡大学第二人民医院儿科，宜昌 443000)

摘　要：摘　要：肺癌是我国最常见的恶性肿瘤，发病率高且预后差。miR-21 可通过转录后调控机制调节多种与细胞增殖、血管生成和侵袭迁移相关的肿瘤抑制因子的表达，在肿瘤的发生发展及转移中发挥重要作用。miR-21 在非小细胞肺癌中高表达，与非小细胞肺癌细胞增殖、血管生成、侵袭和转移密切相关，是一个潜在的肺癌诊断与转移的分子靶标。

Research progress of miR-21 in non-small cell lung cancer

GONG Xue-Wei1， ZHENG Li-Min1， SHENG De-Qiao1*， ZHANG Li-Hua2*

(1 Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy， College of Medical Science of China Three Gorges University， Yichang 443002， China;
    2 Department of Paediatrics， the Second People's Hospital of China Three Gorges University， Yichang 443000， China)

Abstract: Abstract: Lung cancer， with the highest morbidity and poor prognosis， is the most common cause of cancer-related deaths in China. MiR-21 can regulate the expression of a variety of tumor supressor factors related to cell proliferation， angiogenesis， invasion and migration through post-transcriptional regulation， which plays an important role in the development and metastasis of tumor. The high expression of miR-21 in non-small cell lung cancer is closely related to the proliferation， angiogenesis， invasion and metastasis of non-small cell lung cancer， and is a potential molecular target for the diagnosis and metastasis of lung cancer.