(1 三峡大学医学院,肿瘤微环境与免疫治疗湖北省重点实验室,宜昌 443002;2 三峡大学第二人民医院儿科,宜昌 443000)

摘 要:摘 要:肺癌是我国最常见的恶性肿瘤,发病率高且预后差。miR-21 可通过转录后调控机制调节多种与细胞增殖、血管生成和侵袭迁移相关的肿瘤抑制因子的表达,在肿瘤的发生发展及转移中发挥重要作用。miR-21 在非小细胞肺癌中高表达,与非小细胞肺癌细胞增殖、血管生成、侵袭和转移密切相关,是一个潜在的肺癌诊断与转移的分子靶标。

Research progress of miR-21 in non-small cell lung cancer
GONG Xue-Wei1, ZHENG Li-Min1, SHENG De-Qiao1*, ZHANG Li-Hua2*
(1 Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Medical Science of China Three Gorges University, Yichang 443002, China;
    2 Department of Paediatrics, the Second People's Hospital of China Three Gorges University, Yichang 443000, China)

Abstract: Abstract: Lung cancer, with the highest morbidity and poor prognosis, is the most common cause of cancer-related deaths in China. MiR-21 can regulate the expression of a variety of tumor supressor factors related to cell proliferation, angiogenesis, invasion and migration through post-transcriptional regulation, which plays an important role in the development and metastasis of tumor. The high expression of miR-21 in non-small cell lung cancer is closely related to the proliferation, angiogenesis, invasion and metastasis of non-small cell lung cancer, and is a potential molecular target for the diagnosis and metastasis of lung cancer.

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