《生命科学》 2018, 30(7): 752-757

白藜芦醇抑制上皮肿瘤细胞侵袭和迁移的机制

高俊英，季淑华，郑兆娣，李国荣*

(山东师范大学生命科学学院，济南 250014)

摘　要：摘　要：白藜芦醇是一种多酚类的植物抗毒素，具有多种生物学活性，其中，抗肿瘤作用受到人们越来越多的关注。大量实验表明，白藜芦醇具有靶向抑制癌细胞侵袭和迁移的能力。EMT 过程使上皮细胞获得间充质表型，从而促进癌细胞的侵袭和迁移。MicroRNAs 可靶向EMT 的转录因子以及上皮和间充质标志物来调节EMT 过程。MMP-2 和MMP-9 是细胞外基质的两个重要成分，均参与肿瘤细胞的转移。白藜芦醇通过影响EMT 过程、调控microRNAs 家族的表达以及抑制MMPs 的蛋白表达和酶活性来影响上皮肿瘤细胞的侵袭和迁移。现对白藜芦醇抑制上皮肿瘤细胞侵袭、迁移的机制进行综述。

Mechanisms of resveratrol inhibiting the invasion and migration of epithelial tumor cells

GAO Jun-Ying， JI Shu-Hua， ZHENG Zhao-Di， LI Guo-Rong*

(School of Life Sciences， Shandong Normal University， Jinan 250014， China)

Abstract: Abstract: Resveratrol is a polyphenolic phytoalexin that has a variety of biological activities. Its antitumor effect is drawing more and more attention. Experimental data exhibit that resveratrol is able to inhibit the invasion and migration of cancer cells. EMT processes transform mesenchymal phenotypes of epithelial cells to promote invasion and migration of cancer cells. MicroRNAs target transcription factors of EMT as well as the markers of epithelium and mesenchyme to regulate the EMT process. MMP-2 and MMP-9 are two important components of extracellular matrix and involve in metastasis of tumor cells. Resveratrol hinders the invasion and migration of epithelium tumor cells by modulating the EMT process， regulating the expression of microRNAs family and inhibiting the protein expression or enzyme activity of MMPs. In this review， we discussed the molecular mechanisms of resveratrol inhibiting epithelial tumor cells migration and invasion.