《生命科学》 2018, 30(7): 739-745

Apelin/APJ调节鱼类摄食的研究进展

唐　妮，王书瑶，齐锦雯，吴源冰，李志琼*

(四川农业大学动物科技学院，成都 611130)

摘　要：摘　要：Apelin 是1998 年首次从牛胃分泌物中提取出的APJ 的内源性配体，Apelin 及其受体APJ 广泛分布于动物中枢和外周组织中。Apelin 通过与受体APJ 结合，不仅参与血压调节、痛觉调节、体液平衡和细胞凋亡等多种生理过程，还在动物摄食调控和胃肠道运动调节中发挥重要作用。目前，关于Apelin 调控摄食的作用还存在争议。现依据Apelin 和APJ 在哺乳动物和鱼类的研究进展，阐述Apelin 及APJ 的结构、组织分布和对动物摄食的调控及其机制，以期为其在鱼类摄食调控方面的研究提供参考。

The research progress of Apelin/APJ in regulation of fish feeding

TANG Ni， WANG Shu-Yao， QI Jin-Wen， WU Yuan-Bing， LI Zhi-Qiong*

(College of Animal Science and Technology， Sichuan Agricultural University， Chengdu 611130， China)

Abstract: Abstract: Apelin firstly extracted from bovine gastric secretion in 1998 is an endogenous ligand for APJ. Apelin and its receptor APJ are widely distributed in animal central and peripheral tissues. Apelin via binding to receptor APJ not only participates in various physiological processes such as blood pressure regulation， pain modulation， humoral balance and apoptosis， but also plays an important role in animal feeding regulation and gastrointestinal motility. At present， the role of Apelin in regulating food intake is still controversial. Therefore， this paper for providing reference for the research on the regulation of fish feeding， reviews the structure， tissue distribution pattern， the feeding regulation fuction and mechanism of Apelin and APJ based upon the research progress of Apelin and APJ in mammals and fish.