《生命科学》 2018, 30(7): 732-738

MORC家族蛋白的生物学功能研究进展

崔　曦，宁　可，刘芙蓉，李　丰，邵阳光*

(中国医科大学基础医学院分子细胞生物学教研室，国家卫计委细胞生物学重点实验室暨教育部医学细胞生物学重点实验室，沈阳 110122)

摘　要：摘　要：Microrchidia (MORC) 是高度保守的核蛋白超家族，包括MORC1、MORC2、MORC3 和MORC4。MORCs 作为新的表观遗传调控因子，参与多种基本的生物学过程，包括DNA 损伤修复、细胞增殖、细胞衰老和表观遗传调控。MORCs 的调节异常与癌症、自身免疫疾病和骨病相关。对MORCs 结构和功能的进一步研究将为开发治疗MORCs 相关疾病的新方法奠定基础。该文将结合作者的研究工作，重点对MORCs在癌症和骨稳态调节中的作用进行综述，并讨论MORCs 作为癌症、自身免疫疾病和骨病治疗的新药物靶点的可能应用前景。

Research advance in the biological functions of MORC family proteins

CUI Xi， NING Ke， LIU Fu-Rong， LI Feng， SHAO Yang-Guang*

（Department of Molecular Cell Biology， Key Laboratory of Cell Biology， National Health and Family Planning Commission， and Key Laboratory of Medical Cell Biology， Ministry of Education， College of Basic Medical Science， China Medical University， Shenyang 110122， China）

Abstract: Abstract: Microrchidia (MORC)， a highly conserved nuclear protein superfamily， consists of MORC1， MORC2，MORC3 and MORC4. As novel epigenetic regulation factors， MORCs participate in many fundamental biological processes， including DNA repair， cell proliferation， cell senescence and epigenetic regulation. The dysregulation of MORCs has been linked with cancer， autoimmune and bone diseases. Further studies to uncover the structure and function of MORCs is essential for developing new approaches to treat MORCs associated diseases. Based on our results， we review the roles of MORCs in cancer and bone homeostasis， and discuss the potential application of MORCs as novel drug targets to treat cancer， autoimmune and bone diseases.